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This may result in proteins that will not operate, work less successfully, are more quickly degraded, or are present in inadequate numbers. It has been hypothesized that mutations in the CFTR gene might confer a selective advantage to heterozygous people. Cells expressing a mutant type of the CFTR protein are resistant to invasion by the Salmonella typhi bacterium, the agent of typhoid fever, and mice carrying a single copy of mutant CFTR are resistant to diarrhea caused by cholera toxin. An ind...
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